CAS No. 607378-18-7

Batch: Purity:99.11
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AZ10606120 dihydrochloride Chemical Structure
Chemical Structure
Check the AZ10606120 dihydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 607378-18-7
Molecular Formula

C25H36Cl2N4O2
Molecular Weight (MW) 495.48
SMILES Cl.Cl.OCCNCCNC1=NC2=C(C=C1)C(=CC=C2)NC(=O)CC34CC5CC(CC(C5)C3)C4

Ordering Information

Biological Activity

AZ10606120 dihydrochloride is a potent and selective antagonist of the P2X7 receptor. Blockade of P2X7 signaling inhibits downstream receptor-mediated pore formation and suppresses inflammatory cytokine production, including interleukin-1β release. Target inhibition further modulates purinergic pathways involved in neuroinflammation and cell proliferation, leading to antidepressant-like behavioral responses and reduced tumor growth in preclinical disease models. [1]

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 99 mg/mL (199.8 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 17 mg/mL
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.