CAS No. 1370290-34-8
Batch:
Purity:99.12
Chemical Structure
Check the
AZ-33
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-[[4-[4-[[3-[(2-methyl-1,3-benzothiazol-6-yl)amino]-3-oxopropyl]amino]-4-oxobutyl]phenyl]methyl]propanedioic acid | |
|---|---|---|
| CAS Number | 1370290-34-8 | |
| Molecular Formula |
C25H27N3O6S |
|
| Molecular Weight (MW) | 497.56 | |
| SMILES | CC1=NC2=C(S1)C=C(C=C2)NC(=O)CCNC(=O)CCCC3=CC=C(C=C3)CC(C(=O)O)C(=O)O | |
| InChIKey | SGFJAJFBGVAOFW-UHFFFAOYSA-N |
AZ-33 is a small-molecule inhibitor targeting lactate dehydrogenase A (LDHA). By inhibiting LDHA activity, it disrupts the anaerobic glycolysis pathway and suppresses lactate production in glycolytic cancer cells. This metabolic disruption leads to decreased cellular ATP levels, accumulation of reactive oxygen species, and subsequent suppression of cancer cell proliferation and tumor growth. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(200.98 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(200.98 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | ˂1 mg/mL |
| Ethanol | ˂1 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.