CAS No. 1135205-94-5

Batch: Purity:98.26
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AWL-II-38.3 Chemical Structure
Chemical Structure
Check the AWL-II-38.3 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[2-methyl-5-[[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)benzoyl]amino]phenyl]-1,2-oxazole-5-carboxamide
CAS Number 1135205-94-5
Molecular Formula

C23H18F3N5O3
Molecular Weight (MW) 469.42
SMILES CC1=C[N](C=N1)C2=CC(=CC(=C2)C(F)(F)F)C(=O)NC3=CC(=C(C)C=C3)NC(=O)C4=CC=NO4
InChIKey IYUFHBXMTTXZBE-UHFFFAOYSA-N

Biological Activity

AWL-II-38.3 is a potent inhibitor of Ephrin type-A receptor 3 (EphA3) kinase. It functions as a type II kinase inhibitor that stabilizes the inactive DFG-out conformation of the EphA3 kinase domain and induces structural rearrangements in the ATP-binding site. By blocking EphA3 activation, it interrupts downstream receptor tyrosine kinase signaling pathways involved in cell adhesion, migration, and cellular proliferation. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 94 mg/mL (200.24 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 2 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Dong J, et al. ACS Med Chem Lett. 2014;6(1):79-83.

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Note: Technical data last updated: Sep 1, 2026.