CAS No. 188116-07-6
Batch:
Purity:99.92
Chemical Structure
Check the
Imepitoin
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 188116-07-6 | |
|---|---|---|
| Molecular Formula |
C13H14ClN3O2 |
|
| Molecular Weight (MW) | 279.72 | |
| SMILES | C1COCCN1C2=NC(=O)N(C2)C3=CC=C(C=C3)Cl |
Biological Activity
Imepitoin (AWD 131-138) is a centrally acting low-affinity partial agonist targeting the benzodiazepine binding site of the GABAA receptor. By potentiating GABA-mediated inhibitory neurotransmission, imepitoin enhances neuronal inhibition across central nervous system pathways. This downstream mechanism leads to significant anticonvulsant and anxiolytic phenotypes, effective in suppressing seizure activity while demonstrating a favorable safety profile compared to full benzodiazepine agonists.
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
30 mg/mL
(107.25 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 2 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Note: Technical data last updated: Sep 1, 2026.