CAS No. 1983984-01-5
Batch:
Purity:99.01
Chemical Structure
Check the
Avotaciclib trihydrochloride
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2,6-bis(2-aminopyrimidin-4-yl)pyridin-3-ol;trihydrochloride | |
|---|---|---|
| CAS Number | 1983984-01-5 | |
| Molecular Formula |
C13H11N7O.3ClH |
|
| Molecular Weight (MW) | 390.66 | |
| InChIKey | YUNYDIDVURXULR-UHFFFAOYSA-N |
Avotaciclib trihydrochloride is a potent, orally active cyclin-dependent kinase 1 (CDK1) inhibitor. By targeting CDK1, it interrupts cell cycle progression and downstream signaling involved in cell division, leading to the suppression of tumor cell proliferation and induction of apoptosis. These cellular effects support its investigation as a targeted agent in models of locally advanced or metastatic pancreatic cancer.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Water | 78 mg/mL |
| DMSO |
4 mg/mL
(10.23 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
- Avotaciclib trihydrochloride Solubility in DMSO
- Avotaciclib trihydrochloride Stock Solution
- Avotaciclib trihydrochloride Storage
- Avotaciclib trihydrochloride Stability
- Avotaciclib trihydrochloride Molecular Weight
- Avotaciclib trihydrochloride Chemical Structure (2D and 3D)
- Avotaciclib trihydrochloride SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.