🛡️ Hazard Overview
- GHS Class: GHS02; GHS05; GHS06; GHS08; GHS09
- Signal Word: Danger
- Hazard Statements: H260; H300; H311; H314; H317; H330; H334; H361; H372; H373; H400; H410
🧤 PPE Guidelines
- Gloves: Chemical‑resistant gloves suggested
- Eye Protection: Safety goggles suggested
- Respirator: Dust respirator if dust occurs
❄️ Storage
- Storage Temp: -20°C (-4°F) Keep dry
🚑 Emergency First Aid
- For inhalation, skin, eye or ingestion exposure, please refer to full SDS Section 4.
Product identifier
- Product Name: Avermectin B1
- Catalog Number: S4999
- CAS Number: 71751-41-2
- IUPAC Name: Avermectin B1
Relevant identified uses and uses advised against
- Identified uses: For research and development use only; laboratory chemicals; manufacture of substances.
- Uses advised against: Not for pharmaceutical, household, or other unapproved uses.
Details of the supplier
- Company: Selleck Chemicals
- TollFree: +1 877 796-6397
- Tel: +1 832 582-8158
- Fax: +1 832 582-8590
Emergency telephone number
- Emergency phone #: +1 832 582-8158
2.1 GHS classification in accordance with 29 CFR 1910 (OSHA HCS):
Substances which in contact with water emit flammable gases: Category 1. H260
Acute toxicity (oral): Category 1. H300
Acute toxicity (dermal): Category 3. H311
Skin corrosion: Category 1. H314
Skin sensitization: Category 1. H317
Acute toxicity (inhalation): Category 1. H330
Respiratory sensitization: Category 1. H334
Reproductive toxicity: Category 2. H361
Specific target organ toxicity (repeated exposure): Category 1. H372
Specific target organ toxicity (repeated exposure): Category 2. H373
Acute aquatic toxicity: Category 1. H400
Chronic aquatic toxicity: Category 1. H410
2.2 GHS Label elements, including precautionary statements
Hazard Pictogram(s):
Signal Word:
Danger
Hazard statement(s):
H260: In contact with water releases flammable gases which may ignite spontaneously
H300: Fatal if swallowed
H311: Toxic in contact with skin
H314: Causes severe skin burns and eye damage
H317: May cause an allergic skin reaction
H330: Fatal if inhaled
H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled
H361: Suspected of damaging fertility or the unborn child
H372: Causes damage to organs through prolonged or repeated exposure
H373: May causes damage to organs through prolonged or repeated exposure
H400: Very toxic to aquatic life
H410: Very toxic to aquatic life with long lasting effects
Precautionary statement(s):
Prevention:
P203: Obtain, read and follow all safety instructions before use.
P223: Do not allow contact with water.
P231+P232: Handle and store contents under inert gas. Protect from moisture.
P233: Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapors/spray.
P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P272: Contaminated work clothing should not be allowed out of the workplace.
P273: Avoid release to the environment.
P280: Wear protective gloves/protective clothing/eye protection/face protection/hearing protection.
P284: [In case of inadequate ventilation] Wear respiratory protection.
Response:
P301+P316: IF SWALLOWED: Get emergency medical help immediately.
P301+P330: IF SWALLOWED: Rinse mouth.
P302+P335: IF ON SKIN: Brush off loose particles from skin.
P302+P352: IF ON SKIN: wash with plenty of water.
P302+P361: IF ON SKIN: Take off immediately all contaminated clothing.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P305+P354: IF IN EYES: Immediately rinse with water for several minutes.
P316: Get emergency medical help immediately.
P318: if exposed or concerned, get medical advice.
P319: Get medical help if you feel unwell.
P320: Specific treatment is urgent.
P321: Specific treatment (see information on this label and safety datasheet)).
P330: Rinse mouth.
P331: Do NOT induce vomiting.
P333+P317: If skin irritation or rash occurs: Get medical help.
P334: Immerse in cool water [or wrap in wet bandages].
P338: Remove contact lenses, if present and easy to do. Continue rinsing.
P342+P316: If experiencing respiratory symptoms: Get emergence medical help immediately.
P354: Immediately rinse with water for several minutes.
P361+P364: Take off immediately all contaminated clothing and wash it before reuse.
P362+P364: Take off contaminated clothing and wash it before reuse.
P363: Wash contaminated clothing before reuse.
P370+P378: In case of fire: Use water spray, dry chemical, carbon dioxide, or appropriate foam to extinguish.
P391: Collect spillage.
Storage:
P402+P404: Store in a dry place. Store in a closed container.
P403: Store in a well-ventilated place.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
Disposal:
P501: P501 Dispose of contents/ container to an approved waste disposal plant.
2.3 Other hazards
None.
3.1 Substances
Product name: Avermectin B1
CAS Number: 71751-41-2
PubChem CID: 9920327
Molecular formula: C95H142O28
Molecular weight: 1732.1 g/mol
IUPAC name: (1'R,2R,3S,4'S,6S,8'R,10'E,12'S,13'S,14'E,16'E,20'R,21'R,24'S)-2-[(2S)-butan-2-yl]-21',24'-dihydroxy-12'-[(2R,4S,5S,6S)-5-[(2S,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-4-methoxy-6-methyloxan-2-yl]oxy-3,11',13',22'-tetramethylspiro[2,3-dihydropyran-6,6'-3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene]-2'-one;(1'R,2R,3S,4'S,6S,8'R,10'E,12'S,13'S,14'E,16'E,20'R,21'R,24'S)-21',24'-dihydroxy-12'-[(2R,4S,5S,6S)-5-[(2S,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-4-methoxy-6-methyloxan-2-yl]oxy-3,11',13',22'-tetramethyl-2-propan-2-ylspiro[2,3-dihydropyran-6,6'-3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene]-2'-one
3.2 Mixtures
Not applicable (pure substance).
4.1 Description of first aid measures
Inhalation: Move to fresh air. Keep at rest in a position comfortable for breathing. Seek medical attention if symptoms persist.
Skin contact: Wash with plenty of soap and water. Remove contaminated clothing. Seek medical attention if irritation develops.
Eye contact: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. Seek medical attention.
Ingestion: Rinse mouth. Do NOT induce vomiting unless directed by medical personnel. Seek medical attention.
4.2 Most important symptoms and effects, both acute and delayed
See Section 11 (Toxicological Information).
4.3 Indication of any immediate medical attention and special treatment needed
Treat symptomatically. Contact a poison control center or physician for severe exposure.
5.1 Extinguishing media
Suitable: Water spray, dry chemical, carbon dioxide (CO2), alcohol-resistant foam.
Unsuitable: None known.
5.2 Specific hazards arising from the substance or mixture
Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:
SMALL FIRE: Dry chemical, CO2 or water spray.
LARGE FIRE: Dry chemical, CO2, alcohol-resistant foam or water spray. If it can be done safely, move undamaged containers away from the area around the fire. Dike runoff from fire control for later disposal.
FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Do not get water inside containers. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. (ERG, 2024)
Wear self contained breathing apparatus for fire fighting if necessary.
Fire extinguishing media: dry chemical, foam, CO2.
5.3 Advice for firefighters
Wear self-contained breathing apparatus (SCBA) and full protective clothing.
Fight fire from upwind. Cool containers with water spray until fire is extinguished.
6.1 Personal precautions, protective equipment and emergency procedures
Wear appropriate personal protective equipment (see Section 8).
Avoid breathing dust/vapor. Ensure adequate ventilation.
Evacuate personnel to safe areas. Keep people away from and upwind of spill.
WARNING: Highly toxic — only trained personnel should handle spills.
6.2 Environmental precautions
Prevent product from entering drains, waterways, or soil.
Contain spill with inert absorbent material.
6.3 Methods and materials for containment and cleaning up
Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:
IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.
SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.
FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)
Provide appropriate exhaust ventilation at places where dust is formed.
Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.
Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.
SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.
Fatal if swallowed. May be harmful in contact with skin. Harmful if inhaled. Very toxic to aquatic life... Wash hands thorughly after handling. Avoid release to the enviroment. If swallowed: Immediately call a poison center or doctor/physician.
Avoid contact with skin and eyes. Avoid formation of dust and aerosols.
SRP: The scientific literature for the use of contact lenses by industrial workers is inconsistent. The benefits or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.
7.1 Precautions for safe handling
Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:
ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. (ERG, 2024)
Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20 °C. Keep in a dry place.
7.2 Conditions for safe storage, including any incompatibilities
Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20 °C. Keep in a dry place.
Store away from incompatible materials (see Section 10).
[Note: Specific storage temperature not available in public databases. Refer to supplier Certificate of Analysis (COA) for exact storage conditions.]
8.1 Exposure controls
8.1.1 Occupational exposure limits (OEL)
OSHA PEL: Not established.
ACGIH TLV: Not established.
NIOSH REL: Not established.
No occupational exposure limit values are established for this substance.
Use the lowest feasible exposure level (ALARA principle).
8.1.2 Appropriate engineering controls
Use only in a chemical fume hood or with local exhaust ventilation.
Ensure adequate ventilation to keep airborne concentrations below exposure limits.
8.2 Individual protection measures
8.2.1 Eye/face protection
Wear chemical safety goggles and face shield.
8.2.2 Skin protection
Wear protective gloves. Recommended material: Nitrile rubber.
Wear suitable protective clothing (lab coat).
8.2.3 Respiratory protection
Wear NIOSH-approved respirator with appropriate cartridges. SCBA for high concentrations.
8.2.4 Thermal hazards
Not applicable.
9.1 Information on basic physical and chemical properties
a) Appearance: Abamectin appears as odorless off-white to yellow crystals from methanol. Does not hydrolyze in water at pH 3, 5, 7. Used as an acaricide and insecticide.
b) Odor: Odorless
c) Odor threshold: No data available
d) pH: No data available
e) Melting point/freezing point: 150-155 °C
f) Initial boiling point and boiling range: No data available
g) Flash point: No data available
h) Evaporation rate: No data available
i) Flammability (solid, gas): No data available
j) Upper/lower flammability or explosive limits: No data available
k) Vapor pressure: 1.5X10-9 mm Hg at 20 °C
l) Vapor density: No data available
m) Relative density: 1.16 at 21 °C
n) Water solubility: In water, 1.21 mg/L at 25 °C
o) Partition coefficient: n-octanol/water: Log P: No data available
p) Auto-ignition temperature: No data available
q) Decomposition temperature: No data available
r) Viscosity: No data available
s) Explosive properties: No data available
t) Oxidizing properties: No data available
9.2 Other information
Topological Polar Surface Area (TPSA): 340 Ų
Complexity: 3430
10.1 Reactivity
No specific reactivity hazards identified under normal handling conditions.
10.2 Chemical stability
Stable under recommended storage conditions.
10.3 Possibility of hazardous reactions
No hazardous reactions under normal conditions.
10.4 Conditions to avoid
Avoid heat, sparks, open flames, direct sunlight, and moisture.
10.5 Incompatible materials
Strong oxidizing agents, strong acids, strong bases.
10.6 Hazardous decomposition products
Thermal decomposition may produce: Carbon monoxide (CO), Carbon dioxide (CO₂).
See also Section 5 (Fire-fighting measures) for combustion products.
11.1 Information on toxicological effects
Acute toxicity:
Oral Acute Reference Dose (RfDoa)(mg/kg-day): 0.0025
Oral Acute Reference Dose Reference: OPP
Acute or One Day PAD (RfD) [mg/kg/day]: 0.0025
Acute or One Day HHBPs [ppb]: 17
Acute HHBP Sensitive Lifestage/Population: Children
Skin corrosion/irritation:
Causes severe skin burns and eye damage (H314).
Serious eye damage/eye irritation:
No data available.
Respiratory or skin sensitization:
May cause allergy or asthma symptoms or breathing difficulties if inhaled (H334).
Germ cell mutagenicity:
No data available.
Carcinogenicity:
No data available.
Reproductive toxicity:
Suspected of damaging fertility or the unborn child (H361).
Specific target organ toxicity (single exposure):
H372, H373
Specific target organ toxicity (repeated exposure):
No data available.
Aspiration hazard:
No data available.
11.2 Additional information
Carcinogen classification:
Cancer Classification: Group E - Evidence of Non-carcinogenicity for Humans
Data source: Hazardous Substances Data Bank (HSDB) via PubChem.
12.1 Toxicity
LC50; Species: Anas platyrhynchos (Mallard Duck)age 10 days; chemical incorporated into food 383 ppm for 8 days (95% confidence interval: 302-487 ppm)
LC50; Species: Colinus virginianus (Northern Bobwhite Quail) age 14 days; chemical incorporated into food 3102 ppm for 8 days (95% confidence interval: 2344-4415 ppm)
LD50; Species: Anas platyrhynchos (Mallard Duck) age 5 months; oral via capsule 85 mg/kg for 14 days (95% confidence interval: 67-120 mg/kg)
LD50; Species: Colinus virginianus (Northern Bobwhite Quail) age 12 months; oral via capsule >2000 mg/kg for 14 days
For more Ecotoxicity Values (Complete) data for ABAMECTIN (16 total), please visit the HSDB record page.
/AQUATIC SPECIES/ Abamectin is used as an acaricide and insecticide for fruits, vegetables and ornamental plants, as well as a parasiticide for animals. One of the major problems of applying pesticides to crops is the likelihood of contaminating aquatic ecosystems by drift or runoff. Therefore, toxicity tests in the laboratory are important tools to predict the effects of chemical substances in aquatic ecosystems. The aim of this study was to assess the potential hazards of abamectin to the freshwater biota and consequently the possible losses of ecological services in contaminated water bodies. For this purpose, we identified the toxicity of abamectin on daphnids, insects and fish. Abamectin was highly toxic, with an EC(50) 48 hr for Daphnia similis of 5.1 ng /per/ L, LC(50) 96 hr for Chironomus xanthus of
12.2 Persistence and degradability
No data available.
12.3 Bioaccumulative potential
No data available.
12.4 Mobility in soil
No data available.
12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available.
12.6 Other adverse effects
This substance is classified as hazardous to the aquatic environment.
13.1 Waste treatment methods
Waste Treatment Methods: Waste material must be disposed of in accordance with national and local regulations. Leave chemicals in original containers and do not mix with other waste. Handle uncleaned containers in the same manner as the product itself.
14.1 UN number
Not regulated as dangerous goods (research quantities typically exempt).
14.2 UN proper shipping name
Not subject to transport regulations (small quantities for research use).
14.3 Transport hazard class(es)
Not classified as dangerous goods for transport (research quantities).
DOT label: Poison
14.4 Packing group
Not applicable (not regulated as dangerous goods in typical research quantities).
14.5 Environmental hazards
Marine pollutant: Yes (classified as environmentally hazardous per GHS).
14.6 Special precautions for user
Transport in original packaging. Ensure containers are tightly sealed.
For bulk or commercial quantities, consult applicable transport regulations (DOT, IATA, IMDG).
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not applicable.
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
US EPA / TSCA: Subject to EPA TSCA regulations
EU ECHA / REACH: Not available in public databases.
SARA 302 Components:
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.
SARA 313 Components:
This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.
SARA 311/312 Hazards:
Acute (short-term) health hazard
Chronic (long-term) health hazard
Environmental hazard
Fire hazard
Reactive hazard
Massachusetts Right To Know Components:
This material contains components subject to the Massachusetts Right to Know Act. See Section 2 for hazard classification.
Pennsylvania Right To Know Components:
This material contains components subject to the Pennsylvania Right to Know Act. See Section 2 for hazard classification.
New Jersey Right To Know Components:
This material contains components subject to the New Jersey Right to Know Act. See Section 2 for hazard classification.
California Prop. 65 Components:
This product does not contain any chemicals known to the State of California to cause cancer, birth defects, or any other reproductive harm.
Other regulatory listings:
- California Safe Cosmetics Program (CSCP) Reportable Ingredient: Hazard Traits - Developmental Toxicity Authoritative List - Prop 65 Report - regardless of intended function of ingredient in the product
- EFSA Legal Basis: Commission Regulation No 844/2012
- Safe Drinking Water Act: Abamectin is listed in the dataset of EPA Human Health Benchmarks for Pesticides under the Safe Drinking Water Act (40 eCFR 141)
- Status Regulation (EC): 2008/107, Reg. (EU) 2017/438, Reg. (EU) 2019/168, Reg. (EU) 2020/421, Reg. (EU) 2021/566, Reg. (EU) 2022/378, Reg. (EU) 2022/378, Reg. (EU) 2023/515, Reg. (EU) No 540/2011
- New Jersey Worker and Community Right to Know Act: The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)
15.2 Chemical safety assessment
A chemical safety assessment has not been carried out for this substance.
For research-use-only compounds, no CSA is required under REACH Annex I.
Revision Date: 2026/09/09
Further Information: The information provided is believed to be correct but is not exhaustive and should be used only as a guideline based on current knowledge. It does not represent a guarantee of the properties of the product. Selleck Chemicals Corporation and its Affiliates shall not be held liable for any damage resulting from handling or contact with the product.