CAS No. 879127-16-9
Batch:
Purity:99.6
Chemical Structure
Check the
Aurora Kinase Inhibitor III
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[3-[[4-[3-(trifluoromethyl)anilino]pyrimidin-2-yl]amino]phenyl]cyclopropanecarboxamide | |
|---|---|---|
| CAS Number | 879127-16-9 | |
| Molecular Formula |
C21H18F3N5O |
|
| Molecular Weight (MW) | 413.40 | |
| SMILES | C1CC1C(=O)NC2=CC=CC(=C2)NC3=NC=CC(=N3)NC4=CC=CC(=C4)C(F)(F)F | |
| InChIKey | RDTDWGQDFJPTPD-UHFFFAOYSA-N |
Aurora Kinase Inhibitor III is a potent ATP-competitive inhibitor targeting Aurora A kinase with selectivity over other protein kinases such as BMX, BTK, IGF-1R, c-Src, TRKB, SYK, and EGFR. Inhibition of Aurora A kinase disrupts mitotic spindle pole organization and chromosome alignment during mitosis. This perturbation impairs cell cycle progression, leading to G2/M phase arrest, inhibition of cellular proliferation, and induction of apoptotic cell death in cancer cells. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
83 mg/mL
(200.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 5 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
- Aurora Kinase Inhibitor III Solubility in DMSO
- Aurora Kinase Inhibitor III Stock Solution
- Aurora Kinase Inhibitor III Storage
- Aurora Kinase Inhibitor III Stability
- Aurora Kinase Inhibitor III Molecular Weight
- Aurora Kinase Inhibitor III SMILES
- Aurora Kinase Inhibitor III Chemical Structure (2D and 3D)
- Aurora Kinase Inhibitor III SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.