CAS No. 331770-21-9

Batch: Purity:99.41
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Aurora kinase Inhibitor II Chemical Structure
Chemical Structure
Check the Aurora kinase Inhibitor II product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenyl]benzamide
CAS Number 331770-21-9
Molecular Formula

C23H20N4O3
Molecular Weight (MW) 400.43
SMILES COC1=CC2=C(C=C1OC)C(=NC=N2)NC3=CC=C(NC(=O)C4=CC=CC=C4)C=C3
InChIKey IMYVCWQAHSYYOO-UHFFFAOYSA-N

Ordering Information

Biological Activity

Aurora kinase Inhibitor II is a cell-permeable anilinoquinazoline compound that acts as a potent and selective ATP-competitive inhibitor of Aurora kinase (ARK). By targeting Aurora kinase activity, it disrupts critical regulation of the cell cycle, particularly cell division and mitotic spindle assembly. Downstream inhibition of this pathway suppresses tumor cell proliferation and impairs cancer cell growth and progression. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 80 mg/mL (199.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.