CAS No. 3031593-79-7
Batch:
Purity:98.12
Chemical Structure
Check the
AUR1545
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 3-[6-[4-[[1-[4-[(3R,5R)-5-[(5-bromo-1-methyl-6-oxopyridazin-4-yl)amino]-1-methylpiperidin-3-yl]benzoyl]piperidin-4-yl]methyl]piperazin-1-yl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione | |
|---|---|---|
| CAS Number | 3031593-79-7 | |
| Molecular Formula |
C41H50BrN9O5 |
|
| Molecular Weight (MW) | 828.80 | |
| InChIKey | CNPXSLCFWMPKRQ-BFFVTFPMSA-N |
AUR1545 is a potent and selective degrader targeting lysine acetyltransferases KAT2A and KAT2B. Targeted degradation of KAT2A and KAT2B disrupts histone acetylation and epigenetic transcriptional regulation, leading to anti-proliferative activity in cancer cells. Furthermore, loss of KAT2A and KAT2B function downregulates oncogenic gene expression pathways and significantly inhibits tumor growth in an NCI-H1048 xenograft model. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
50 mg/mL
(60.32 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(120.65 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.