CAS No. 35543-24-9

Batch: Purity:99.87
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Buflomedil HCl Chemical Structure
Chemical Structure
Check the Buflomedil HCl product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 35543-24-9
Molecular Formula

C17H25NO4.HCl
Molecular Weight (MW) 343.85
SMILES COC1=CC(=C(C(=C1)OC)C(=O)CCCN2CCCC2)OC.Cl

Biological Activity

Buflomedil HCl is a vasoactive agent that functions as a nonselective alpha-adrenergic receptor inhibitor. By blocking alpha-1 and alpha-2 adrenoceptors in vascular smooth muscle, it attenuates sympathetic vasoconstriction and restores microvascular perfusion. Additionally, buflomedil inhibits platelet aggregation and improves erythrocyte deformability, thereby enhancing microcirculatory blood flow and reducing vascular resistance in peripheral arterial disease.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 69 mg/mL
DMSO 31 mg/mL (90.15 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 7 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Note: Technical data last updated: Sep 1, 2026.