CAS No. 35543-24-9
| CAS Number | 35543-24-9 | |
|---|---|---|
| Molecular Formula |
C17H25NO4.HCl |
|
| Molecular Weight (MW) | 343.85 | |
| SMILES | COC1=CC(=C(C(=C1)OC)C(=O)CCCN2CCCC2)OC.Cl |
Buflomedil HCl is a vasoactive agent that functions as a nonselective alpha-adrenergic receptor inhibitor. By blocking alpha-1 and alpha-2 adrenoceptors in vascular smooth muscle, it attenuates sympathetic vasoconstriction and restores microvascular perfusion. Additionally, buflomedil inhibits platelet aggregation and improves erythrocyte deformability, thereby enhancing microcirculatory blood flow and reducing vascular resistance in peripheral arterial disease.
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| Water | 69 mg/mL |
| DMSO |
31 mg/mL
(90.15 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 7 mg/mL |
| Water | 69 mg/mL |
| DMSO |
31 mg/mL
(90.15 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 7 mg/mL |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
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