CAS No. 479-98-1
Batch:
Purity:99.5
Chemical Structure
Check the
Aucubin
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 479-98-1 | |
|---|---|---|
| Molecular Formula |
C15H22O9 |
|
| Molecular Weight (MW) | 346.33 | |
| SMILES | C1=COC(C2C1C(C=C2CO)O)OC3C(C(C(C(O3)CO)O)O)O |
Aucubin is a naturally occurring iridoid glycoside that exhibits marked anti-inflammatory and cytoprotective activities. It suppresses lipopolysaccharide-induced gene expression and production of key pro-inflammatory cytokines, including TNF-α, by inhibiting the activation of the NF-κB signaling pathway in murine macrophages. Consequently, this inhibition leads to reduced cellular inflammatory responses and protects tissues against oxidative stress and inflammatory injury in preclinical models.
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
69 mg/mL
(199.23 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 15 mg/mL |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.