CAS No. 2973395-71-8

Batch: Purity:98.88
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ATX968 Chemical Structure
Chemical Structure
Check the ATX968 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[3-chloro-5-(methanesulfonamido)phenyl]-4-(3-methyl-2-pyridinyl)thiophene-2-carboxamide
CAS Number 2973395-71-8
Molecular Formula

C18H16ClN3O3S2
Molecular Weight (MW) 421.92
InChIKey VDGNPEFFHQRGOP-UHFFFAOYSA-N

Biological Activity

ATX968 is a potent and selective small-molecule inhibitor of the DHX9 RNA helicase. By targeting DHX9, it disrupts nuclear RNA helicase function and genomic stability pathways, leading to suppressed RNA processing and accumulation of lethal R-loops. This inhibition impairs cell proliferation and induces sustained tumor growth regression, particularly in microsatellite instability-high and mismatch repair-deficient colorectal cancer models.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 84 mg/mL (199.08 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.