CAS No. 1414943-88-6
| IUPAC Name | 4-(4-fluoro-2-methoxyphenyl)-N-[3-[(methylsulfonimidoyl)methyl]phenyl]-1,3,5-triazin-2-amine | |
|---|---|---|
| CAS Number | 1414943-88-6 | |
| Molecular Formula |
C18H18FN5O2S |
|
| Molecular Weight (MW) | 387.43 | |
| SMILES | COC1=C(C=CC(=C1)F)C2=NC(=NC=N2)NC3=CC=CC(=C3)CS(=N)(=O)C | |
| InChIKey | ACWKGTGIJRCOOM-UHFFFAOYSA-N |
Atuveciclib (BAY-1143572) is a potent, selective P-TEFb/CDK9 inhibitor that targets CDK9/CycT (IC50 13 nM), showing about 100-fold selectivity over CDK2 while inhibiting GSK3α (IC50 45 nM) and GSK3β (IC50 87 nM). By targeting CDK9, it suppresses RNA polymerase II C-terminal domain phosphorylation, disrupting transcriptional elongation. This pathway blockade selectively downregulates short-lived oncogenic and anti-apoptotic proteins such as MYC and MCL1, ultimately triggering apoptosis in tumor cells.
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
77 mg/mL
(198.74 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
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- Atuveciclib (BAY-1143572) Clinical Trials
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- Atuveciclib (BAY-1143572) Stock Solution
- Atuveciclib (BAY-1143572) Storage
- Atuveciclib (BAY-1143572) Stability
- Atuveciclib (BAY-1143572) Molecular Weight
- Atuveciclib (BAY-1143572) SMILES
- Atuveciclib (BAY-1143572) Chemical Structure (2D and 3D)
- Atuveciclib (BAY-1143572) SDS｜MSDS