CAS No. 104054-27-5
Batch:
Purity:99.89
Chemical Structure
Check the
Atipamezole
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 104054-27-5 | |
|---|---|---|
| Molecular Formula |
C14H16N2 |
|
| Molecular Weight (MW) | 212.29 | |
| SMILES | CCC1(CC2=CC=CC=C2C1)C3=CN=CN3 |
Biological Activity
Atipamezole is a synthetic α2 adrenergic receptor antagonist. By blocking presynaptic and postsynaptic α2 adrenergic receptors, it counteracts α2 adrenoceptor-mediated signaling pathways, preventing agonist-induced suppression of neurotransmitter release. Consequently, this competitive antagonism enhances central noradrenergic activity, modulating vigilance, cognitive processing, and motor behavior while reversing sedations and physiological responses triggered by selective α2 adrenoceptor activation.
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
42 mg/mL
(197.84 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 42 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Note: Technical data last updated: Sep 1, 2026.