CAS No. 104075-48-1

Batch: Purity:99.56
Check CoA
Atipamezole hydrochloride Chemical Structure
Chemical Structure
Check the Atipamezole hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 104075-48-1
Molecular Formula

C14H16N2.HCl
Molecular Weight (MW) 248.75
SMILES CCC1(CC2=CC=CC=C2C1)C3=CN=CN3.Cl

Ordering Information

Biological Activity

Atipamezole hydrochloride is a synthetic and highly selective α2-adrenergic receptor antagonist. By competitively blocking central and peripheral α2-adrenergic receptors, it potently reverses α2-adrenoceptor agonist-induced sedation and related physiological effects. Inhibiting these receptors promotes central noradrenaline turnover and enhances overall noradrenergic neurotransmission, downstream modulating locomotor activity, alertness, and behavioral responses in preclinical animal models.

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Ethanol 49 mg/mL
Water 21 mg/mL
DMSO 12 mg/mL (48.24 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Jump to

Note: Technical data last updated: Sep 1, 2026.