CAS No. 1226895-20-0
Batch:
Purity:99.11
Chemical Structure
Check the
ATB 346
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (4-carbamothioylphenyl) 2-(6-methoxynaphthalen-2-yl)propanoate | |
|---|---|---|
| CAS Number | 1226895-20-0 | |
| Molecular Formula |
C21H19NO3S |
|
| Molecular Weight (MW) | 365.45 | |
| SMILES | CC(C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)OC3=CC=C(C=C3)C(=S)N | |
| InChIKey | YCNMAPLPQYQJFC-UHFFFAOYSA-N |
ATB-346 is a novel hydrogen sulfide-releasing derivative of naproxen that acts as an inhibitor of cyclooxygenase (COX) activity. By suppressing COX-mediated pro-inflammatory pathways while delivering hydrogen sulfide, ATB-346 effectively attenuates inflammatory signaling and reduces gastrointestinal mucosal toxicity. Furthermore, ATB-346 suppresses cell proliferation and induces apoptosis in human melanoma cells, demonstrating robust anti-inflammatory and antineoplastic phenotypes in preclinical models. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
73 mg/mL
(199.75 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.