CAS No. 1219962-49-8
Batch:
Purity:98.08
Chemical Structure
Check the
AT791
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 3-[4-[6-[3-(dimethylamino)propoxy]-1,3-benzoxazol-2-yl]phenoxy]-N,N-dimethylpropan-1-amine | |
|---|---|---|
| CAS Number | 1219962-49-8 | |
| Molecular Formula |
C23H31N3O3 |
|
| Molecular Weight (MW) | 397.51 | |
| InChIKey | JKFYWFWUJUHSMZ-UHFFFAOYSA-N |
AT791 is an orally bioavailable dual inhibitor targeting Toll-like receptor 7 (TLR7) and Toll-like receptor 9 (TLR9). By blocking ligand recognition and DNA-TLR9 binding, AT791 attenuates downstream MyD88-dependent activation pathways, suppressing NF-kB nuclear translocation and downstream pro-inflammatory cytokine production. This targeted inhibition effectively downregulates innate immune signaling cascades driven by endosomal pattern recognition receptors in cellular models. [1][2]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
80 mg/mL
(201.25 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 20 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.