CAS No. 912999-49-6
Batch:
Purity:99.94
Chemical Structure
Check the
Onalespib (AT13387)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (2,4-dihydroxy-5-propan-2-ylphenyl)-[5-[(4-methylpiperazin-1-yl)methyl]-1,3-dihydroisoindol-2-yl]methanone | |
|---|---|---|
| CAS Number | 912999-49-6 | |
| Molecular Formula |
C24H31N3O3 |
|
| Molecular Weight (MW) | 409.52 | |
| SMILES | CC(C)C1=CC(=C(C=C1O)O)C(=O)N2CC3=C(C2)C=C(C=C3)CN4CCN(CC4)C | |
| InChIKey | IFRGXKKQHBVPCQ-UHFFFAOYSA-N |
Onalespib (AT13387) is a potent, selective heat shock protein 90 (Hsp90) inhibitor that binds Hsp90 with a Kd of 0.7 nM. In cellular assays, AT13387 demonstrates anti-proliferative activity across cancer cell lines, inhibiting A375 (IC50 18 nM), MV4-11 (IC50 12 nM), NCI-H1975 (IC50 22 nM), and SKBr3 (IC50 55 nM) growth. By destabilizing Hsp90 client proteins, it disrupts oncogenic signaling to induce apoptosis and suppress tumor cell proliferation. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
25 mg/mL
(61.04 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
25 mg/mL
(61.04 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
82 mg/mL
(200.23 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
82 mg/mL
(200.23 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 82 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Onalespib (AT13387) Clinical Trials
- Onalespib (AT13387) Solubility in DMSO
- Onalespib (AT13387) Stock Solution
- Onalespib (AT13387) Storage
- Onalespib (AT13387) Stability
- Onalespib (AT13387) Molecular Weight
- Onalespib (AT13387) SMILES
- Onalespib (AT13387) Chemical Structure (2D and 3D)
- Onalespib (AT13387) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.