CAS No. 162640-98-4
Batch:
Purity:98.52
Chemical Structure
Check the
AT-56
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 1-[4-(2H-tetrazol-5-yl)butyl]-4-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,9,11,13-heptaenylidene)piperidine | |
|---|---|---|
| CAS Number | 162640-98-4 | |
| Molecular Formula |
C25H27N5 |
|
| Molecular Weight (MW) | 397.52 | |
| SMILES | C1CN(CCC1=C2C3=CC=CC=C3C=CC4=CC=CC=C42)CCCCC5=NNN=N5 | |
| InChIKey | LQNGMDUIRLSESZ-UHFFFAOYSA-N |
Biological Activity
AT-56 is a selective, orally active inhibitor of lipocalin-type prostaglandin D synthase (L-PGDS). By blocking L-PGDS, it prevents the conversion of prostaglandin H2 into prostaglandin D2, suppressing downstream PGD2-mediated signaling pathways. This targeted enzyme inhibition affects PGD2-regulated physiological processes, including lipid metabolism, inflammatory responses, and central nervous system functions in biological models.
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
80 mg/mL
(201.24 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Note: Technical data last updated: Sep 1, 2026.