CAS No. 2170729-29-8
Batch:
Purity:99.57
Chemical Structure
Check the
Govorestat
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-[4-oxo-3-[[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl]thieno[3,4-d]pyridazin-1-yl]acetic acid | |
|---|---|---|
| CAS Number | 2170729-29-8 | |
| Molecular Formula |
C17H10F3N3O3S2 |
|
| Molecular Weight (MW) | 425.41 | |
| SMILES | C1=CC2=C(C=C1C(F)(F)F)N=C(S2)CN3C(=O)C4=CSC=C4C(=N3)CC(=O)O | |
| InChIKey | ORQGHAJIWGGFJK-UHFFFAOYSA-N |
Govorestat (AT-007) is an orally active, brain-penetrant aldose reductase inhibitor used in research on classic galactosemia. By targeting aldose reductase within the polyol pathway, it suppresses the conversion of excess galactose into toxic galactitol. This reduction in galactitol accumulation prevents osmotic stress, oxidative damage, and downstream tissue toxicity caused by galactose-1-phosphate uridyltransferase deficiency.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
85 mg/mL
(199.8 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.