CAS No. 2095719-92-7

Batch: Purity:99.91
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ASTX-029 Chemical Structure
Chemical Structure
Check the ASTX-029 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (2R)-2-[5-[5-chloro-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxo-1H-isoindol-2-yl]-N-[(1S)-1-(3-fluoro-5-methoxyphenyl)-2-hydroxyethyl]propanamide
CAS Number 2095719-92-7
Molecular Formula

C29H31ClFN5O5
Molecular Weight (MW) 584.04
SMILES COC1=CC(=CC(=C1)C(CO)NC(=O)C(C)N2CC3=CC=C(C=C3C2=O)C4=NC(=NC=C4Cl)NC5CCOCC5)F
InChIKey BVRGQPJKSKKGIH-PUAOIOHZSA-N

Ordering Information

Biological Activity

ASTX-029 is an orally bioavailable and selective small-molecule inhibitor of extracellular signal-regulated kinases 1 and 2 (ERK1/2). By directly inhibiting ERK1/2 within the MAPK signaling cascade, ASTX-029 prevents downstream phosphorylation events and signaling to key transcriptional regulators. This blockade suppresses ERK-dependent tumor cell proliferation, induces cell cycle arrest, and promotes cell death in MAPK pathway-driven malignant cells.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (171.22 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 50 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.