CAS No. 1453208-66-6
Batch:
Purity:99.93
Chemical Structure
Check the
ASP5878
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-[4-[[5-[(2,6-difluoro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl]amino]pyrazol-1-yl]ethanol | |
|---|---|---|
| CAS Number | 1453208-66-6 | |
| Molecular Formula |
C18H19F2N5O4 |
|
| Molecular Weight (MW) | 407.37 | |
| SMILES | COC1=CC(=C(C(=C1F)COC2=CN=C(N=C2)NC3=CN(N=C3)CCO)F)OC | |
| InChIKey | VDZZYOJYLLNBTD-UHFFFAOYSA-N |
ASP5878 is a novel fibroblast growth factor receptor inhibitor targeting recombinant FGFR1 (IC50 0.47 nmol/L), FGFR2 (IC50 0.60 nmol/L), FGFR3 (IC50 0.74 nmol/L), and FGFR4 (IC50 3.5 nmol/L). By blocking FGFR kinase activity, it suppresses downstream MAPK/ERK and AKT/mTOR signaling pathways, leading to the inhibition of cell proliferation, migration, and tumor growth in FGFR-dependent cancer models.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
81 mg/mL
(198.83 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 4 mg/mL |
| Water | Insoluble |
| DMSO |
81 mg/mL
(198.83 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.