CAS No. 2241719-73-1
Batch:
Purity:98.07
Chemical Structure
Check the
ASP2453
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-[7-[6-cyclopropyl-2-[1-(3-methoxypropyl)piperidin-4-yl]oxy-7-(5-methyl-1H-indazol-4-yl)-8-(2,2,2-trifluoroethoxy)quinazolin-4-yl]-2,7-diazaspiro[3.5]nonan-2-yl]prop-2-en-1-one | |
|---|---|---|
| CAS Number | 2241719-73-1 | |
| Molecular Formula |
C40H48F3N7O4 |
|
| Molecular Weight (MW) | 747.85 | |
| InChIKey | VEXDXXFHISGELS-UHFFFAOYSA-N |
ASP2453 is a potent, selective, and covalent KRAS G12C inhibitor. It effectively disrupts the Son of Sevenless (SOS)-mediated interaction between KRAS G12C and Raf, suppressing downstream MAPK signaling pathways including ERK phosphorylation. Through this targeted inhibition, ASP2453 blocks cell proliferation and exhibits robust antitumor activity across KRAS G12C-mutated preclinical cancer models. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(133.71 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.