CAS No. 2541792-70-3
Batch:
Purity:99.39
Chemical Structure
Check the
ASK1-IN-2
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 6-fluoro-N-[6-(4-propan-2-yl-1,2,4-triazol-3-yl)-2-pyridinyl]-1H-indole-2-carboxamide | |
|---|---|---|
| CAS Number | 2541792-70-3 | |
| Molecular Formula |
C19H17FN6O |
|
| Molecular Weight (MW) | 364.38 | |
| SMILES | CC(C)[N]1C=NN=C1C2=CC=CC(=N2)NC(=O)C3=CC4=C([NH]3)C=C(F)C=C4 | |
| InChIKey | LYUQNMNUBOUCBX-UHFFFAOYSA-N |
ASK1-IN-2 is a potent, orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with an ICof. By selectively suppressing ASK1, it blocks downstream MAPK signaling pathways, including ASK1-p38 and JNK cascades. This inhibition attenuates the production of inflammatory cytokines and reduces tissue damage in preclinical models of ulcerative colitis. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
73 mg/mL
(200.34 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.