CAS No. 1638281-46-5
Batch:
Purity:99.84
Chemical Structure
Check the
Asandeutertinib
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[2-[2-(dimethylamino)ethyl-methylamino]-4-methoxy-5-[[4-[1-(trideuteriomethyl)indol-3-yl]pyrimidin-2-yl]amino]phenyl]prop-2-enamide | |
|---|---|---|
| CAS Number | 1638281-46-5 | |
| Molecular Formula |
C28H30D3N7O2 |
|
| Molecular Weight (MW) | 502.63 | |
| InChIKey | DUYJMQONPNNFPI-VPYROQPTSA-N |
Asandeutertinib is a deuterated, third-generation, ATP-competitive, and irreversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor. As a deuterium-stabilized derivative of osimertinib, it selectively targets mutant forms of EGFR, inhibiting downstream signaling through the EGFR pathway, including the RAS/RAF/MEK/ERK and PI3K/AKT/mTOR cascades. Blockade of these pathways suppresses cell proliferation and induces apoptosis in EGFR-mutated non-small cell lung cancer models. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(198.95 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 5 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.