CAS No. 2241300-51-4
Batch:
Purity:99.89
Chemical Structure
Check the
AS2863619
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-[1-(2-methyl-3H-benzimidazol-5-yl)imidazo[4,5-c]pyridin-2-yl]-1,2,5-oxadiazol-3-amine;dihydrochloride | |
|---|---|---|
| CAS Number | 2241300-51-4 | |
| Molecular Formula |
C16H14Cl2N8O |
|
| Molecular Weight (MW) | 405.24 | |
| SMILES | CC1=NC2=C(N1)C=C(C=C2)N3C4=C(C=NC=C4)N=C3C5=NON=C5N.Cl.Cl | |
| InChIKey | LHUAALWRORLTCJ-UHFFFAOYSA-N |
AS2863619 is a potent small-molecule inhibitor of cyclin-dependent kinases CDK8 and CDK19. As a Mediator complex kinase component, CDK8 regulates beta-catenin activity and CTD-dependent transcriptional machinery. Inhibition of CDK8 suppresses CTD-dependent gene expression and modulates downstream phenotypes, including promoting Foxp3 induction in conventional T cells. [1][2]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Water | 81 mg/mL |
| DMSO |
60 mg/mL
(148.06 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 4 mg/mL |
| DMSO |
81 mg/mL
(199.88 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 50 mg/mL |
| Ethanol | ˂1 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
- AS2863619 Mechanism of Action: CDK8/19 Inhibition in CD4+ T Cell Research
- AS2863619 Working Concentration | Cell Culture | Treatment
- AS2863619 Solubility in DMSO
- AS2863619 Stock Solution
- AS2863619 Storage
- AS2863619 Stability
- AS2863619 Combination Database
- AS2863619 Molecular Weight
- AS2863619 SMILES
- AS2863619 Chemical Structure (2D and 3D)
- AS2863619 MedChemExpress (HY-126675A)? Try a better option.
- AS2863619 APExBIO (BA3757)? Try a better option.
- AS2863619 Cayman (30976)? Try a better option.
- AS2863619 SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.