CAS No. 836620-48-5
Batch:
Purity:99.87
Chemical Structure
Check the
AS1842856
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 5-amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-4-oxoquinoline-3-carboxylic acid | |
|---|---|---|
| CAS Number | 836620-48-5 | |
| Molecular Formula |
C18H22FN3O3 |
|
| Molecular Weight (MW) | 347.38 | |
| SMILES | CCN1C=C(C(=O)C2=C1C=C(C(=C2N)F)NC3CCCCC3)C(=O)O | |
| InChIKey | MOMCHYGXXYBDCD-UHFFFAOYSA-N |
Biological Activity
AS1842856 is a cell-permeable inhibitor of Foxo1 transcription activity with an IC50 of 33 nM. It selectively binds to active, unphosphorylated Foxo1 rather than the Ser256-phosphorylated protein, effectively blocking Foxo1 transactivation. Through the inhibition of Foxo1-driven gene transcription, AS1842856 suppresses downstream cellular pathways such as autophagy and gluconeogenesis, thereby regulating metabolic phenotypes and cellular homeostasis.
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
5 mg/mL
(14.39 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
2 mg/mL
(5.75 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Jump to
- AS1842856 Mechanism of Action: FOXO1 Inhibition in Cancer Cell Research
- AS1842856 Working Concentration | Cell Culture | Treatment
- AS1842856 Solubility in DMSO
- AS1842856 Stock Solution
- AS1842856 Storage
- AS1842856 Stability
- AS1842856 Combination Database
- AS1842856 Molecular Weight
- AS1842856 SMILES
- AS1842856 Chemical Structure (2D and 3D)
- AS1842856 IC50 for Cell-based and Cell-free Assays
- AS1842856 MedChemExpress (HY-100596)? Try a better option.
- AS1842856 Sigma (344355)? Try a better option.
- AS1842856 Cayman (16761)? Try a better option.
- AS1842856 SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.