CAS No. 919486-40-1
| IUPAC Name | 4-(benzylamino)-2-[2-(3-chloro-4-hydroxyphenyl)ethylamino]pyrimidine-5-carboxamide | |
|---|---|---|
| CAS Number | 919486-40-1 | |
| Molecular Formula |
C20H20ClN5O2 |
|
| Molecular Weight (MW) | 397.86 | |
| SMILES | C1=CC=C(C=C1)CNC2=NC(=NC=C2C(=O)N)NCCC3=CC(=C(C=C3)O)Cl | |
| InChIKey | OZRMEKAUZBKTTC-UHFFFAOYSA-N |
AS1517499 is a potent and selective STAT6 inhibitor with an IC50 of. By inhibiting STAT6 activation, the compound disrupts interleukin-4 (IL-4)-mediated signaling pathways and downregulates STAT6-dependent gene transcription. This pharmacological inhibition leads to downstream cellular phenotypes including reduced expression of Th2 cytokines, suppression of antigen-induced airway hyperresponsiveness, attenuation of goblet cell hyperplasia, and marked inhibition of eosinophil infiltration in preclinical asthma models. [1]
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
79 mg/mL
(198.56 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 36 mg/mL |
| Water | Insoluble |
| DMSO |
80 mg/mL
(201.07 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 20 mg/mL |
| Water | Insoluble |
| DMSO |
80 mg/mL
(201.07 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 20 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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