CAS No. 1949837-12-0

Batch: Purity:99.27
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ARV-771 Chemical Structure
Chemical Structure
Check the ARV-771 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (2S,4R)-1-[(2S)-2-[[2-[3-[2-[[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]amino]ethoxy]propoxy]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide
CAS Number 1949837-12-0
Molecular Formula

C49H60ClN9O7S2
Molecular Weight (MW) 986.64
SMILES CC1=C(SC2=C1C(=NC(C3=NN=C(N32)C)CC(=O)NCCOCCCOCC(=O)NC(C(=O)N4CC(CC4C(=O)NC(C)C5=CC=C(C=C5)C6=C(N=CS6)C)O)C(C)(C)C)C7=CC=C(C=C7)Cl)C
InChIKey PQOGZKGXGLHDGS-QQRWPDCKSA-N

Ordering Information

Biological Activity

ARV-771 is a potent pan-bromodomain and extra-terminal (BET) degrader that targets BET proteins including BRD2, BRD3, and BRD4. As a von Hippel-Lindau (VHL)-based proteolysis-targeting chimera (PROTAC), ARV-771 induces von Hippel-Lindau-dependent polyubiquitination and proteasomal degradation of BET family members. This selective degradation suppresses c-Myc expression and downstream oncogenic signaling pathways, inhibiting cell proliferation and driving apoptosis in castration-resistant prostate cancer models. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (101.35 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 100 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.