CAS No. 2607139-85-3
Batch:
Purity:99.49
Chemical Structure
Check the
ART899
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (2S,3S,4S)-N-(3-chloro-4-fluorophenyl)-3,4-dihydroxy-1-[6-methyl-4-(trifluoromethyl)-2-pyridinyl]-5-oxo-N-(trideuteriomethyl)pyrrolidine-2-carboxamide | |
|---|---|---|
| CAS Number | 2607139-85-3 | |
| Molecular Formula |
C19H13ClD3F4N3O4 |
|
| Molecular Weight (MW) | 464.82 | |
| InChIKey | YJJOABOMFPGRED-YQCADYNBSA-N |
ART899 is a potent and specific allosteric inhibitor of DNA polymerase theta (Polθ), targeting its microhomology-mediated end joining (MMEJ) activity. By selectively impairing Polθ-mediated DNA damage repair during cell replication, ART899 disrupts downstream repair pathways and potently radiosensitizes tumor cells under both normoxic and hypoxic microenvironments. Consequently, ART899 enhances radiation efficacy, promoting sustained tumor growth inhibition and cell death in cancer models without causing radiosensitization in noncancerous tissues. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(215.13 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
- ART899 Mechanism of Action: Polθ Inhibition in Tumor Cells Research
- ART899 Working Concentration | Cell Culture | Treatment
- ART899 Solubility in DMSO
- ART899 Stock Solution
- ART899 Storage
- ART899 Stability
- ART899 Combination Database
- ART899 Molecular Weight
- ART899 Chemical Structure (2D and 3D)
- ART899 IC50 for Cell-based and Cell-free Assays
- ART899 MedChemExpress (HY-139289S)? Try a better option.
- ART899 AdooQ (A24284)? Try a better option.
- ART899 SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.