CAS No. 2607138-82-7
Batch:
Purity:99.62
Chemical Structure
Check the
ART812
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (2S,3S,4S)-N-(3-chloro-4-fluorophenyl)-3,4-dihydroxy-N-methyl-1-[6-methyl-4-(trifluoromethyl)-2-pyridinyl]-5-oxopyrrolidine-2-carboxamide | |
|---|---|---|
| CAS Number | 2607138-82-7 | |
| Molecular Formula |
C19H16ClF4N3O4 |
|
| Molecular Weight (MW) | 461.80 | |
| InChIKey | YJJOABOMFPGRED-JYJNAYRXSA-N |
ART812 is an orally active DNA polymerase theta (Polθ) inhibitor. By targeting Polθ, it disrupts microhomology-mediated DNA double-strand break repair, a critical pathway for resolving DNA damage in homologous recombination-deficient cells. Inhibition occurs through stabilization of a closed enzyme conformation, leading to synthetic lethality and robust antitumor activity in preclinical models of PARP inhibitor-resistant triple-negative breast cancer. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
92 mg/mL
(199.22 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 92 mg/mL |
| Water | Insoluble |
| DMSO |
92 mg/mL
(199.22 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 92 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.