CAS No. 2267316-76-5

Batch: Purity:99.86
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ART0380 (Alnodesertib) Chemical Structure
Chemical Structure
Check the ART0380 (Alnodesertib) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-[4-[(cyclopropyl-methyl-oxo-λ6-sulfanylidene)amino]-6-[(3R)-3-methylmorpholin-4-yl]pyrimidin-2-yl]pyridin-2-amine
CAS Number 2267316-76-5
Molecular Formula

C18H24N6O2S
Molecular Weight (MW) 388.49
InChIKey JHPDHYAMSPMBIF-ZJGDTTMNSA-N

Biological Activity

ART0380 is a potent and selective ATP-competitive ATR kinase inhibitor that targets the ATR-ATRIP complex. By suppressing ATR activity, it disrupts DNA damage response signaling, abolishes cell cycle checkpoints, and impairs replication stress tolerance. This leads to persistent DNA damage accumulation, replication catastrophe, and inhibition of tumor cell growth, particularly sensitizing cancer cells with loss-of-function defects in ATM-mediated signaling.[1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 78 mg/mL (200.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 9 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Carroll CL, et al. J Med Chem. 2024;67(24):21890-21904.

[2] Pilié PG, et al. Clin Cancer Res. 2024;30(10):2121-2139.

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Note: Technical data last updated: Sep 1, 2026.