CAS No. 1613710-01-2
Batch:
Purity:99.02
Chemical Structure
Check the
ARN-3236
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 3-(2,4-dimethoxyphenyl)-4-thiophen-3-yl-1H-pyrrolo[2,3-b]pyridine | |
|---|---|---|
| CAS Number | 1613710-01-2 | |
| Molecular Formula |
C19H16N2O2S |
|
| Molecular Weight (MW) | 336.41 | |
| SMILES | COC1=CC(=C(C=C1)C2=CNC3=NC=CC(=C23)C4=CSC=C4)OC | |
| InChIKey | WEHOIIGXTMKVRG-UHFFFAOYSA-N |
ARN-3236 is a potent and selective small-molecule inhibitor of salt-inducible kinase 2 (SIK2). As a centrosomal kinase, SIK2 plays a critical role in regulating centrosome splitting, bipolar spindle assembly, and cell cycle progression. Blockade of SIK2 activity downregulates AKT pathway signaling, impairs mitotic spindle integrity, and promotes apoptotic cell death in cancer cells. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
67 mg/mL
(199.16 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 7 mg/mL |
| Water | Insoluble |
| DMSO |
67 mg/mL
(199.16 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 2 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.