CAS No. 313-67-7

Batch: Purity:99.99
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Aristolochic acid A Chemical Structure
Chemical Structure
Check the Aristolochic acid A product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 8-methoxy-6-nitronaphtho[2,1-g][1,3]benzodioxole-5-carboxylic acid
CAS Number 313-67-7
Molecular Formula

C17H11NO7
Molecular Weight (MW) 341.27
SMILES COC1=CC=CC2=C3C(=C(C=C21)[N+](=O)[O-])C(=CC4=C3OCO4)C(=O)O
InChIKey BBFQZRXNYIEMAW-UHFFFAOYSA-N

Ordering Information

Biological Activity

Aristolochic acid A is a plant-derived carcinogenic, mutagenic, and nephrotoxic agent that targets intracellular signaling pathways and causes genomic instability. It suppresses activator protein 1 (AP-1) and nuclear factor-κB (NF-κB) activities, downregulating downstream transcriptional programs involved in inflammatory responses and cell survival. Furthermore, aristolochic acid A induces characteristic A:T to T:A gene mutations and DNA damage, leading to cellular toxicity and carcinogenesis. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 34 mg/mL (99.62 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.