CAS No. 1259305-29-7
Batch:
Purity:99.72
Chemical Structure
Check the
Aripiprazole lauroxil
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 1259305-29-7 | |
|---|---|---|
| Molecular Formula |
C36H51Cl2N3O4 |
|
| Molecular Weight (MW) | 660.72 |
Biological Activity
Aripiprazole lauroxil is an extended-release prodrug of aripiprazole that functions as a dopamine-serotonin system stabilizer. Upon cleavage to its active form, it acts as a partial agonist at dopamine D2 receptors and serotonin 5-HT1A receptors, while potently antagonizing serotonin 5-HT2A receptors. This balanced modulation of dopaminergic and serotonergic signaling pathways regulates neurotransmitter release and neuronal excitability, contributing to antipsychotic phenotypes. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Ethanol | 7 mg/mL |
| DMSO |
6 mg/mL
(9.08 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.