CAS No. 91-75-8
Batch:
Purity:99.63
Chemical Structure
Check the
Antazoline
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 91-75-8 | |
|---|---|---|
| Molecular Formula |
C17H19N3 |
|
| Molecular Weight (MW) | 265.35 | |
| SMILES | C1CN=C(N1)CN(CC2=CC=CC=C2)C3=CC=CC=C3 |
Antazoline is a first-generation histamine H1 receptor antagonist that selectively blocks histamine-mediated signaling pathways. By competing with endogenous histamine for binding to the G-protein-coupled H1 receptor, it inhibits downstream phosphoinositide hydrolysis and calcium mobilization. This blockade suppresses histamine-induced vascular permeability and smooth muscle contraction, leading to vasoconstrictive effects that reduce capillary lumen diameter and diminish tissue edema.
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
53 mg/mL
(199.73 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 53 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.