CAS No. 80306-38-3
Batch:
Purity:99.87
Chemical Structure
Check the
AR7
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 7-chloro-3-(4-methylphenyl)-2H-1,4-benzoxazine | |
|---|---|---|
| CAS Number | 80306-38-3 | |
| Molecular Formula |
C15H12ClNO |
|
| Molecular Weight (MW) | 257.71 | |
| SMILES | CC1=CC=C(C=C1)C2=NC3=C(C=C(C=C3)Cl)OC2 | |
| InChIKey | MVOZLTFXYGHZPM-UHFFFAOYSA-N |
Biological Activity
AR7 is a retinoic acid receptor α (RARα) antagonist that selectively activates chaperone-mediated autophagy (CMA). By targeting RARα, AR7 modulates RARα-mediated inhibitory signaling, leading to upregulation of the lysosomal receptor LAMP2A and enhancement of substrate clearance through the CMA pathway. Consequently, AR7 protects cells from oxidative stress and proteotoxicity in cellular models of neurodegenerative disorders. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
4 mg/mL
(15.52 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
Jump to
Note: Technical data last updated: Sep 1, 2026.