CAS No. 2002381-31-7

Batch: Purity:99.26
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APS-2-79 HCl Chemical Structure
Chemical Structure
Check the APS-2-79 HCl product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 2002381-31-7
Molecular Formula

C23H21N3O3.HCl
Molecular Weight (MW) 423.89
SMILES CC1=C(C=CC(=C1)OC2=CC=CC=C2)NC3=NC=NC4=CC(=C(C=C43)OC)OC.Cl

Biological Activity

APS-2-79 HCl is a small-molecule MAPK signaling antagonist that targets the Kinase Suppressor of Ras (KSR) scaffold protein. It modulates KSR-dependent signaling by inhibiting RAF heterodimerization and preventing the conformational changes required for the phosphorylation and activation of KSR-bound MEK. Through this mechanism, APS-2-79 suppresses downstream RAS/MAPK pathway activation and attenuates oncogenic cell proliferation. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 97 mg/mL (228.83 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 32 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Brennan DF, et al. Nature. 2011;472(7343):366-9.

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Note: Technical data last updated: Sep 1, 2026.