CAS No. 1103522-45-7
Batch:
Purity:97.31
Chemical Structure
Check the
Aprocitentan
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 1103522-45-7 | |
|---|---|---|
| Molecular Formula |
C16H14Br2N6O4S |
|
| Molecular Weight (MW) | 546.19 |
Biological Activity
Aprocitentan (ACT-132577) is an orally active dual antagonist of endothelin receptor type A (ETA) and endothelin receptor type B (ETB), operating as the active metabolite of macitentan. By inhibiting endothelin-1 binding to ETA and ETB receptors, aprocitentan blocks downstream endothelin signaling pathways, thereby suppressing intracellular calcium influx and attenuating vascular smooth muscle cell contraction to regulate vascular tone. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(183.08 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.