CAS No. 2752441-61-3
Batch:
Purity:98.07
Chemical Structure
Check the
APL-4098
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 2752441-61-3 | |
|---|---|---|
| Molecular Formula |
C17H12ClFN6O3S |
|
| Molecular Weight (MW) | 434.83 |
APL-4098 is an orally active, selective, ATP-competitive inhibitor targeting general control nonderepressible 2 (GCN2, also known as EIF2AK4). By inhibiting GCN2 kinase activity, APL-4098 impairs mitochondrial function and triggers the mitochondrial unfolded protein response. This pathway disruption leads to marked cytotoxicity in primary acute myeloid leukemia (AML) cells and leukemia stem cells. The GCN2-mediated stress response pathway is essential for maintaining cellular homeostasis and survival under nutrient deprivation and metabolic stress conditions. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
87 mg/mL
(200.07 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.