CAS No. 578-74-5

Batch: Purity:99.29
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Apigetrin Chemical Structure
Chemical Structure
Check the Apigetrin product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 578-74-5
Molecular Formula

C21H20O10
Molecular Weight (MW) 432.38
SMILES C1=CC(=CC=C1C2=CC(=O)C3=C(C=C(C=C3O2)OC4C(C(C(C(O4)CO)O)O)O)O)O

Biological Activity

Apigetrin is a natural flavonoid that exhibits potent antioxidant, anti-inflammatory, and antineoplastic activities. It modulates intracellular reactive oxygen species levels and regulates MAPK signaling pathways, downregulating cell survival networks to induce extrinsic apoptosis, autophagy, and necroptosis in cancer cells. Through these signaling cascades, apigetrin suppresses tumor cell proliferation and inhibits pro-inflammatory mediator production in cellular models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 86 mg/mL (198.89 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] ParkYG, et al. Int. J. Aeronaut. Space Sci. 2019;20(3):761-767.

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Note: Technical data last updated: Sep 1, 2026.