CAS No. 945966-46-1
Batch:
Purity:99.80
Chemical Structure
Check the
Apararenone
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 945966-46-1 | |
|---|---|---|
| Molecular Formula |
C17H17FN2O4S |
|
| Molecular Weight (MW) | 364.39 | |
| SMILES | CC1(C)OC2=CC(=CC=C2N(C1=O)C3=CC=C(F)C=C3)N[S;v6](C)(=O)=O |
Apararenone (MT-3995) is a selective, long-acting nonsteroidal mineralocorticoid receptor (MR) antagonist. By competitively inhibiting MR nuclear translocation and transcriptional activity, it attenuates downstream signaling cascades that govern renal sodium reabsorption and extracellular fluid volume. Consequently, this targeted receptor antagonism reduces aldosterone-driven gene expression, preventing vascular inflammation, renal tissue injury, and elevated blood pressure in animal disease models.
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
73 mg/mL
(200.33 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.