CAS No. 84176-65-8
Batch:
Purity:99.86
Chemical Structure
Check the
Antimalarial agent 1
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 84176-65-8 | |
|---|---|---|
| Molecular Formula |
C12H18N6.H3O4P |
|
| Molecular Weight (MW) | 344.31 | |
| SMILES | CC(C)C1=NC2=C(N=C1C(C)C)C(=NC(=N2)N)N.OOPOO |
Antimalarial agent 1 is a pteridine-based antimalarial agent that targets dihydrofolate reductase within the folate metabolic pathway. By inhibiting folate synthesis, it impairs nucleic acid biosynthesis and suppresses protozoal proliferation. Preclinical evaluations demonstrate potent antiplasmodial activity against Plasmodium gallinaceum, including proguanil- and sulphadiazine-resistant strains, leading to reduced parasitemia and inhibition of parasite growth.
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
69 mg/mL
(200.4 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 4 mg/mL |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.