CAS No. 118525-40-9

Batch: Purity:99.58
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Anhydroicaritin Chemical Structure
Chemical Structure
Check the Anhydroicaritin product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 3,5,7-trihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)chromen-4-one
CAS Number 118525-40-9
Molecular Formula

C21H20O6
Molecular Weight (MW) 368.38
SMILES CC(=CCC1=C2C(=C(C=C1O)O)C(=O)C(=C(O2)C3=CC=C(C=C3)OC)O)C
InChIKey TUUXBSASAQJECY-UHFFFAOYSA-N

Ordering Information

Biological Activity

Anhydroicaritin (Cycloicaritin) is a natural prenylated flavonoid that acts as a potent inhibitor of sterol regulatory element-binding proteins (SREBPs). By suppressing SREBP-mediated transcriptional signaling, it regulates lipid metabolism and modulates cell survival pathways. It inhibits cancer cell growth, induces cell apoptosis, protects against beta-amyloid-induced neurotoxicity, and promotes neuronal and cardiac cellular differentiation. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 24 mg/mL (65.15 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 4 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.