CAS No. 2761969-44-0
Batch:
Purity:99.48
Chemical Structure
Check the
Angiotensin II human TFA
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (3S)-3-amino-4-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[(2S)-2-[[(1S)-1-carboxy-2-phenylethyl]carbamoyl]pyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-oxobutanoic acid;2,2,2-trifluoroacetic acid | |
|---|---|---|
| CAS Number | 2761969-44-0 | |
| Molecular Formula |
C50H71N13O12.xC2HF3O2 |
|
| InChIKey | FYMJZKAYBCZPKL-PIONDTTLSA-N |
Angiotensin II human TFA is a primary bioactive peptide of the renin-angiotensin system that acts as an endogenous agonist at angiotensin II type 1 (AT1R) and type 2 (AT2R) receptors. Activation of these receptors regulates cardiovascular homeostasis and renal function by stimulating sympathetic activity and aldosterone secretion. Downstream signaling through redox-sensitive pathways promotes vascular smooth muscle cell proliferation, collagen synthesis, tissue fibrosis, and vasoconstriction. [1][2]
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | 100 mg/mL |
| Ethanol | 4 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.