CAS No. 1313613-09-0

Batch: Purity:99.41
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AMZ30 Chemical Structure
Chemical Structure
Check the AMZ30 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (E)-2-(4-fluorophenyl)sulfonyl-3-[1-(3-nitrophenyl)sulfonylpyrrol-2-yl]prop-2-enenitrile
CAS Number 1313613-09-0
Molecular Formula

C19H12FN3O6S2
Molecular Weight (MW) 461.44
SMILES C1=CC(=CC(=C1)S(=O)(=O)N2C=CC=C2C=C(C#N)S(=O)(=O)C3=CC=C(C=C3)F)[N+](=O)[O-]
InChIKey GUCUORSUHTZMBW-YBFXNURJSA-N

Biological Activity

AMZ30 is a selective and covalent inhibitor of protein phosphatase methylesterase-1 (PME-1). By binding covalently to PME-1, AMZ30 inhibits its demethylase activity and prevents the demethylation of protein phosphatase 2A (PP2A). Consequently, AMZ30 reduces the demethylated form of PP2A in living cells, thereby restoring PP2A-mediated phosphatase functions and regulating downstream signaling pathways that control cellular proliferation and homeostasis. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 92 mg/mL (199.37 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Xing Y, et al. Cell. 2008;133(1):154-63.

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Note: Technical data last updated: Sep 1, 2026.