CAS No. 926023-82-7
Batch:
Purity:98.98
Chemical Structure
Check the
AMTB hydrochloride
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 926023-82-7 | |
|---|---|---|
| Molecular Formula |
C23H26N2O2S.ClH |
|
| Molecular Weight (MW) | 430.99 |
AMTB hydrochloride is a selective blocker of the transient receptor potential melastatin 8 (TRPM8) ion channel (pIC50 6.23). Blockade of TRPM8 suppresses icilin-induced calcium influx, thereby blunting downstream sensory signaling pathways. This inhibition reduces sensory afferent nerve excitability, ultimately leading to diminished bladder rhythmic contractions and attenuation of localized bladder hyperactivity in preclinical models. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
86 mg/mL
(199.54 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 21 mg/mL |
| Water | 20 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.