CAS No. 1393653-34-3
Batch:
Purity:99.77
Chemical Structure
Check the
Narmafotinib
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 2-[2-[2-[2-[2-methoxy-4-(1-methylpiperidin-4-yl)anilino]-5-(trifluoromethyl)pyrimidin-4-yl]ethyl]phenyl]acetamide | |
|---|---|---|
| CAS Number | 1393653-34-3 | |
| Molecular Formula |
C28H32F3N5O2 |
|
| Molecular Weight (MW) | 527.58 | |
| InChIKey | AWJVIOYPZZZYAX-UHFFFAOYSA-N |
Biological Activity
Narmafotinib (AMP- is a small-molecule inhibitor targeting focal adhesion kinase (FAK). Inhibition of the FAK signaling pathway disrupts integrin-mediated downstream signaling, suppressing FAK autophosphorylation and focal adhesion complex turnover. These effects attenuate cancer cell proliferation, migration, and invasion while modulating extracellular matrix remodeling and fibrotic stroma within the tumor microenvironment, thereby promoting apoptosis and impairing tumor growth. [1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
50 mg/mL
(94.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.