CAS No. 14028-44-5
Batch:
Purity:99.22
Chemical Structure
Check the
Amoxapine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 8-chloro-6-piperazin-1-ylbenzo[b][1,4]benzoxazepine | |
|---|---|---|
| CAS Number | 14028-44-5 | |
| Molecular Formula |
C17H16ClN3O |
|
| Molecular Weight (MW) | 313.78 | |
| SMILES | C1CN(CCN1)C2=NC3=CC=CC=C3OC4=C2C=C(C=C4)Cl | |
| InChIKey | QWGDMFLQWFTERH-UHFFFAOYSA-N |
Biological Activity
Amoxapine is a tricyclic dibenzoxazepine derivative that acts as a monoamine reuptake inhibitor and neurotransmitter receptor antagonist, capable of inhibiting GLYT2a transport activity. By modulating central monoamine systems, it blocks serotonin and norepinephrine reuptake and interacts with central dopamine and serotonin receptors. These activities regulate downstream neurotransmitter-mediated signaling pathways, suppressing monoamine transporter function and altering neural cell responses. [1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
3.1 mg/mL
(9.87 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
Jump to
Note: Technical data last updated: Sep 1, 2026.