CAS No. 69-44-3

Batch: Purity:98
Check CoA
Amodiaquine hydrochloride Chemical Structure
Chemical Structure
Check the Amodiaquine hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-[(7-chloroquinolin-4-yl)amino]-2-(diethylaminomethyl)phenol;dihydrate;dihydrochloride
CAS Number 69-44-3
Molecular Formula

C20H22ClN3O.2HCl
Molecular Weight (MW) 428.78
SMILES CCN(CC)CC1=C(C=CC(=C1)NC2=C3C=CC(=CC3=NC=C2)Cl)O.Cl.Cl
InChIKey YVNAYSHNIILOJS-UHFFFAOYSA-N

Ordering Information

Biological Activity

Amodiaquine hydrochloride is an orally active 4-aminoquinoline derivative that acts as an agonist of the orphan nuclear receptor Nurr1 and possesses antimalarial and anti-inflammatory properties. Binding to the ligand-binding domain of Nurr1 enhances transcriptional activity, modulating dopamine signaling pathways and suppressing neuroinflammation. This downstream mechanism protects dopaminergic neurons and rescues behavioral deficits in animal models of Parkinson's disease.

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 56 mg/mL (130.6 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Jump to

Note: Technical data last updated: Sep 1, 2026.